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Fill & Finish

Fill & Finish

Vetter is one of the industry’s leading providers of sterile fill and finish services for parenteral drug manufacturing, including prefilled syringes, cartridges, and vials. We have expertise as a clinical and commercial contract filler for a wide range of biopharmaceutical compounds, including biologics. Our parenteral fill and finish services cover every step along the manufacturing process – development, filling, lyophilization, visual inspection, labeling, and packaging.

Vetter has 4 independent manufacturing facilities to enable the highest quality fill and finish services. Each facility is state-of-the-art and features:

Aseptic filling of syringes

Visual inspection of prefilled syringes, cartridges and vials

Packaging of parenteral products

Comprehensive fill and finish

Vetter offers a broad range of parenteral fill and finish services and can support your compound throughout the entire sterile manufacturing process.

Formulation support

Development support to optimize preformulated API, as well as to identify the strongest of several prequalified drug formulations. (Preformulation and formulation on request.)

Process design and development

A comprehensive range of services designed to meet your goal of a fast, smooth transfer of your project in the clinical phase through to commercial manufacturing.

Production of clinical batches

A broad range of production services for clinical trial material, from compounding to primary packaging to filling / lyophilizing.

Commercial scale-up

Scale-up from the small-scale process developed in the lab to a commercially viable, robust process using a Quality by Design approach. Expertise in lyophilization scale-up, commercial scale process, formal GMP validation, stability batches, and regulatory support at each step.

Production of commercial batches

Extensive production services for commercial drug products, from compounding to primary packaging to filling and lyophilizing.

Visual inspection

Manual or automated visual inspection to enable the highest quality manufacturing processes and end product.

Packaging & labeling

Comprehensive menu of parenteral packaging services, including assembly, printing and labeling, blister packing and cartoning, and storage.

Supply Chain Management

Comprehensive support in compliance management, import/export customs management, transportation, and logistics (including both cold and room temperature storage).

Global regulatory support

Expert documentation and consultation services throughout all phases of regulatory submission and post-approval. Vetter provides in-depth knowledge of global requirements, including FDA, EMA, PMDA (Japan), Paul Ehrlich Institut (Germany) and BfArM (Germany).

Vetter's Fill & finishing capacities

  2 facilities in Ravensburg,
Germany
1 facility in Langenargen,
Germany
1 facility in Chicago (Skokie), USA
cGMP clinical filling
cGMP commercial filling  
Liquid and lyophilized vial filling
Prefilled syringe filling
Cartridge filling  

Vetter is a global leader in the aseptic fill & finish contract manufacturing

Vetter’s fill and finish systems

Vetter’s fill and finish systems Vial fill & finish

Liquid vials

  • Crimp cap and flip-off cap option
  • Multiple formats

Lyophilized vials

  • Crimp cap and flip-off cap option
  • Multiple formats
Syringe fill & finish Syringe fill & finish

Bulk single-chamber syringes

  • Staked needle
  • V-OVS® tamper-evident closure/ tip cap
  • Vetter-Ject® syringe closure system
  • Multiple ml formats

Presterilized single-chamber syringes

  • Staked needle and Luer lock
  • Multiple ml formats

sWFI (sterile Water for Injection) syringes

  • V-OVS® tamper-evident closure
  • 1.5 ml and 3.0 ml formats

Dual-chamber syringes

  • V-OVS® tamper-evident closure
  • Lyophilized/liquid or liquid/liquid
  • 1.0 ml, 2.5 ml, and 5.0 ml formats
Cartridge fill Cartridge fill & finish

Single-chamber cartridges

  • Crimp cap
  • Multiple ml formats

Dual-chamber cartridges

  • V-LK®
  • Lyophilized/liquid or liquid/liquid
  • 1.0 ml format