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Article | A Closer Look at Prefilled Syringes - Choosing between presterilized and bulk sterilized prefilled syringes

Article | A Closer Look at Prefilled Syringes - Choosing between presterilized and bulk sterilized prefilled syringes

Medium: Pharmaceutical Technology
Author: Kevin J. Wrigley

The compound presented several challenges in achieving these requirements. To reduce the silicone levels of the glass barrels and stoppers, the CDMO employed a static siliconization and customized a bulk, baked-in siliconization process. Static siliconization offers a high amount of precision with the ability to adjust silicone levels. During the siliconization process, there is no contact between the silicone nozzle and the glass barrel, which is an important criteria for some specific indication areas such as ophthalmic medications. Baked-in siliconization is the process of the siliconized syringe undergoing dry heat sterilization. Due to the high temperature, the silicone oil is baked into the syringe, thereby minimizing the risk of loose silicone oil droplets coming into contact with the drug substance. In addition, non-siliconized equipment was used so...
 

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A Closer Look at Prefilled Syringes - Choosing between presterilized and bulk sterilized prefilled syringes.

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