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Fill & Finish

Aseptic fill and finish contract manufacturing

Vetter is one of the industry’s leading providers of sterile fill and finish services for parenteral drug manufacturing, including prefilled syringes, cartridges, and vials. We have expertise as a clinical and commercial contract filler for a wide range of biopharmaceutical compounds, including biologics. Our parenteral fill and finish services cover every step along the manufacturing process – development, filling, lyophilization, visual inspection, labeling, and packaging.

Vetter has 4 independent manufacturing facilities to enable the highest quality fill and finish services. Each facility is state-of-the-art and features:

  • Restricted Access Barrier Systems (RABS) technology to enable a high level of sterility
  • Dedicated analytical and microbiological testing resources
  • 100% visual inspection processes
Aseptic filling of syringes (as well as cartridges and vials) Visual inspection of prefilled syringes, cartridges and vials Packaging of parenteral products

Comprehensive fill and finish

Vetter offers a broad range of parenteral fill and finish services and can support your compound throughout the entire sterile manufacturing process.

  Development support to optimize preformulated API, as well as to identify the strongest of several prequalified drug formulations. (Preformulation and formulation on request.)
  A comprehensive range of services designed to meet your goal of a fast, smooth transfer of your project in the clinical phase through to commercial manufacturing.
  A broad range of production services for clinical trial material, from compounding to primary packaging to filling / lyophilizing.
  Scale-up from the small-scale process developed in the lab to a commercially viable, robust process using a Quality by Design approach. Expertise in lyophilization scale-up, commercial scale process, formal GMP validation, stability batches, and regulatory support at each step.
  Extensive production services for commercial drug products, from compounding to primary packaging to filling and lyophilizing.
  Manual or automated visual inspection to enable the highest quality manufacturing processes and end product.
  Comprehensive menu of parenteral packaging services, including assembly, printing and labeling, blister packing and cartoning, and storage.
  Comprehensive support in compliance management, import/export customs management, transportation, and logistics (including both cold and room temperature storage).
  Expert documentation and consultation services throughout all phases of regulatory submission and post-approval. Vetter provides in-depth knowledge of global requirements, including FDA, EMA, PMDA (Japan), and RP (Germany).
  2 facilities in Ravensburg,
Germany
1 facility in Langenargen,
Germany
1 facility in Chicago (Skokie), USA
cGMP clinical filling
cGMP commercial filling  
Liquid and lyophilized vial filling
Prefilled syringe filling
Cartridge filling  
 

See how Vetter can support you already in clinical phases of your parenteral drug product 

 

See what Vetter can offer you for commercial supply of your parenteral drug product 

 

See our comprehensive menu of drug delivery systems and packaging services that can be customized to your products‘ needs 

 

 

Vetter’s fill and finish systems

Liquid vials
  • Crimp cap and flip-off cap option
  • Multiple formats
Lyophilized vials
  • Crimp cap and flip-off cap option
  • Multiple formats

Bulk single-chamber syringes
  • Staked needle
  • V-OVS® tamper-evident closure/ tip cap
  • Multiple ml formats
Presterilized single-chamber syringes
  • Staked needle and Luer lock
  • Multiple ml formats
sWFI (sterile Water for Injection) syringes
  • V-OVS® tamper-evident closure
  • 1.5 ml and 3.0 ml formats
Dual-chamber syringes
  • V-OVS® tamper-evident closure
  • Lyophilized/liquid or liquid/liquid
  • 1.0 ml, 2.5 ml, and 5.0 ml formats

Single-chamber cartridges
  • Crimp cap
  • Multiple ml formats
Dual-chamber cartridges
  • V-LK®
  • Lyophilized/liquid or liquid/liquid
  • 1.0 ml format